J. Vicente, I. Saura-Llamas, D. Bautista
Oct 26, 2005
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0
Influential Citations
38
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Journal
Organometallics
Abstract
Phentermine hydrochloride ((PhCH2CMe2NH3)Cl) or l-tryptophan methyl ester hydrochloride ([C8H6NCH2CH(CO2Me)NH3]Cl) reacts with Pd(OAc)2 in a 1:1 molar ratio to give the cyclometalated complex [Pd2(κ2-C,N-C6H4CH2CMe2NH2-2)2(μ-Cl)2] (1) or (S,S)-[Pd2{κ2-C,N-C8H5NCH2CH(CO2Me)NH2-2}2(μ-Cl)2] (2), respectively. Reaction of 1 or 2 with iodine affords trans-[PdCl2(NH2CMe2CH2C6H4I-2)2] (3) or trans-(S,S)-[PdCl2{NH2CH(CO2Me)CH2C8H5NI-2}2] (4), which further reacts with 1,10-phenanthroline to give [PdCl2(phen)] and the free amine 2-I-phentermine (5) or (S)-2-I-tryptophan methyl ester (6) (overall yields 44 and 51%, respectively, considering phentermine and l-tryptophan methyl ester as starting materials). The crystal structure of complex 3 has been determined by X-ray diffraction studies.