J. Bonjoch, N. Casamitjana, J. Quirante
1987
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron
Abstract
Abstract An improved method for the synthesis of 4-azatricyclo [5.2.2.04,8] undecan-11-one (1) is reported. The synthesis involves hydrogenolysis of 8-hydroxyethyl-2-azabicyclo [3.3.1] nonan-7-one 3 followed by intramolecular alkylation of the resulting secondary amine 7. The required azabicyclic alcohol 3 was obtained by oxidative cyclization with mercuric acetate of the α-alkylated methyl 4-piperidineacetoacetate 5.