H. W. Dickenson, R. Allan, J. Ong
Apr 12, 1988
Citations
0
Influential Citations
11
Citations
Quality indicators
Journal
Neuroscience Letters
Abstract
The activity of Z-5-aminopent-2-enoic acid (A), a conformationally restricted analogue of delta-aminovaleric acid, was investigated in vitro in the guinea pig isolated ileum and vas deferens. A was found to be a relatively potent GABAB-receptor antagonist and a relatively weak GABAA-receptor agonist. The GABAB-receptor antagonist activity of A was at least 5 times greater than that of phaclofen, a selective GABAB-receptor antagonist. A may therefore be an important lead for the development of new potent and selective GABAB-antagonists.