S. Bessman, Sandra J. Skolnik
Mar 6, 1964
Citations
0
Influential Citations
43
Citations
Journal
Science
Abstract
Gamma-hydroxybutyric acid, when administered to animals or human beings, causes sleep. It is convertible to gamma-butyrolactone, which also produces sleep. Tissue concentrations in rats after administration of these two compounds show that the induced sleep is related to the concentration of the lactone in the brain.