G. Leach
Sep 1, 1957
Citations
0
Influential Citations
16
Citations
Journal
Journal of Pharmacy and Pharmacology
Abstract
Dimethylphenylpiperazinium iodide (DMPP) blocks transmission of preganglionic nerve impulses at the superior cervical ganglion of the cat. This effect is augmented by subsequent addition of acetylcholine. It also depresses the emptying reaction, but has no effect on the longitudinal muscle contraction, caused by transmural stimulation of the guinea pig ileum. DMPP appears to block transmission in the same way as does tetramethylammonium, and large doses of acetylcholine.