J. Guilford, Eugene Hichman, E. Eugere
1980
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Journal
Drug Development and Industrial Pharmacy
Abstract
AbstractA gas-liquid chromatographic method for the determination of 2-(o-chlorophenyl)-2-(p-chlorophenyl)-acetic acid in human blood and urine has been developed. The procedure is based on ether extraction of acidified whole blood or urine, derivatization with boron trifluoride-methanol, and GLC analvsia. This method can detect 0.1 uq/ml of compound in blood. Analysis of blood and urine from human volunteers indicated that the procedure is suitabla for pharmacokinetics studies and clinical monitoring of patients.