W. Diamantis, J. Melton, R. Sofia
Mar 15, 1980
Citations
1
Influential Citations
19
Citations
Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
Abstract Gastric ulcerogenicity was evaluated 2, 4, 6, and 24 hr after acute oral administration of various nonsteroidal anti-inflammatory drugs (NSAIDs) to 18-hr fasted rats and the time of peak ulcerogenesis determined. Meseclazone (7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo-[3,2-b][1,3]-benzoxazin-9-one) was found to be the least ulcerogenic of the NSAIDs tested. Unlike the other drugs tested ulcerogenesis was not evident until the 24-hr observation period and only at the highest dose (640.0 mg/kg). The other NSAIDs exhibited gastric damage within 2–4 hr and, in order of ascending ulcerogenicity, were: diflunisal