H. Toshida, K. Nakata, T. Hamano
2002
Citations
0
Influential Citations
35
Citations
Quality indicators
Journal
Advances in experimental medicine and biology
Abstract
Geranyl farnesylacetate (gefarnate) has been used to stimulate mucin production from goblet cells of patients who have gastritis and/or gastric ulcer.1,2 In previous studies, Nakamura et al.3 reported that gefarnate increased the mucin-like glycoprotein secretion from cultured rat corneas in vitro in a dose-dependent manner. The ability of topically applied gefarnate to increase goblet cell density in vivo was reported in normal4,5 and dry eye rabbit.5,6 In the present study, we investigated the effect of topical gefarnate treatment in a rabbit model of dry eye on goblet cell repopulation of the tarsal conjunctiva after a mild alkali injury.