Evgeniy V. Blyumin, H. Neunhoeffer, Yulian V. Volovenko
Jul 1, 2007
Citations
0
Influential Citations
2
Citations
Journal
Synthetic Communications
Abstract
Abstract A facile synthetic approach to 2‐amino‐5‐halogen‐pyrimidine‐4‐carboxylic acids from 5‐halogen‐2‐methylsulfonylpyrimidine‐4‐carboxylic acid by nucleophilic displacement of the methylsulfonyl group with primary and secondary aliphatic amines has been developed. The titled amino acids underwent decarboxylation, yielding 2‐amino‐5‐halogenpyrimidines. Starting from 2‐amino‐5‐chloropyrimidine‐4‐carboxylic acid chlorides, 2‐[5‐chloro‐2‐(amino)‐4‐pyrimidinyl]‐2‐oxo‐1‐(2‐pyridyl)‐ethyl cyanides were obtained in excellent yields.