D. Mohapatra, D. Mondal, M. Chorghade
Dec 25, 2006
Citations
0
Influential Citations
9
Citations
Journal
Tetrahedron Letters
Abstract
The non-proteinogenic amino acid 3-hydroxy-4-methylproline (HMP) is an active constituent of some potent antimicrobials including echinocandins, nostopeptins, pneumocandins, sporiofungin and mulundocandins. A synthesis has been achieved in 10 steps with 29% overall yield; the Evans’ aldol reaction using Crimmins’ modified method was pivotal to the success of the strategy.