D. Tejedor, Leandro Cotos, Gabriela Méndez-Abt
Oct 14, 2014
Citations
0
Influential Citations
35
Citations
Journal
The Journal of organic chemistry
Abstract
A general and practical metal-free protocol for the synthesis of 1,2-dihydropyridines with wide structural/functional diversity at the ring and featuring mono, double, or spiro substitution at the sp(3) position is described. The protocol entails a microwave-assisted domino reaction of a propargyl vinyl ether (secondary or tertiary) and a primary amine (aliphatic or aromatic) in toluene or methanol.