S. Ohta, S. Hayakawa, M. Okamoto
Apr 16, 1985
Citations
0
Influential Citations
6
Citations
Journal
Tetrahedron Letters
Abstract
1-Methyl-2-(1′-cyano-1′-trimethylsilyloxy)alkyl-1H-imidazoles (2) were easily prepared from the corresponding stable carbonyl compounds, 1-methyl-2-acyl- 1H-imidazoles (1). When the quarternary salts of 2 were treated with various nucleophiles, reactive acyl species, which was presumed to be acylcyanide (12), was generated in situ under CC bond fission to result in producing the corresponding acylated compounds (5–10) in good yields.