A. Nagaki, Yusuke Takahashi, J. Yoshida
Apr 18, 2016
Citations
0
Influential Citations
51
Citations
Journal
Angewandte Chemie
Abstract
Using a flow microreactor system, carbamoyllithium compounds were successfully generated and used for reactions with electrophiles to give various amides, including α-ketoamides. The present method could be applied to the three-component synthesis of functionalized α-ketoamides using a carbamoyllithium compound, methyl chloroformate, and a functionalized organolithium reagent.