Atsushi Ueno, N. Ae, H. Terauchi
Aug 12, 2015
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Journal
Organic Process Research & Development
Abstract
A second generation process for benzyl piperidine 10 is described. By the use of a Horner–Wadsworth–Emmons reaction and selective hydrogenation with Pt/C in ethyl acetate, 2-bromo-5-(hydroxymethyl) phenol 14 was efficiently converted to the compound 10 on a 5 kg scale. A small amount of water was found to be critical to complete the selective hydrogenation with low levels of debrominated byproduct 15. Impurities of the compound 10 were controlled by limiting the quality of 2-bromo-5-(hydroxymethyl) phenol 14 and 1-bromo-2-methoxyethane 15.