G. Reysset, W. Su, M. Sebald
1993
Citations
0
Influential Citations
14
Citations
Journal
Journal name not available for this finding
Abstract
Nitroimidazoles are imidazoles that contain a nitro group at position 2, 4, or 5 of the imidazole ring. These compounds may have various substitutions on the nitrogen at position 1 of the imidazole ring. The 5-nitroimidazoles are synthetic compounds that appear to be very potent anaerobicidal agents. Three derivatives are commonly used in clinical therapy: metronidazole [1-(2-hydroxyethyl)-2-methyl-5-nitro-imidazole], ornidazole [1-(3-chloro-2-hydroxy-propyl) 2-methyl-5-nitroimidazole], and tinidα-zole (ethyl [2-(2-methyl-5-nitro-1-imidazolyl)-ethyl] sulfone). They are used extensively for treatment of infections from anaerobic eucaryotes (Entamoeba histolytica, Trichomonas vaginalis, Giardia) and anaerobic procaryotes, having a bactericidal effect against all anaerobic bacteria except the genera Bifidobacterium, Propionibacterium, and Actinomyces.