Yijun Huang, A. Dömling
Feb 1, 2011
Citations
1
Influential Citations
132
Citations
Quality indicators
Journal
Molecular Diversity
Abstract
The Gewald reaction of sulfur, cyanoacetic acid derivatives, and oxo-component (G-3CR) yielding highly substituted 2-aminothiophene derivatives has seen diverse applications in combinatorial and medicinal chemistry. Its products are of great use in pharmaceutical industry mainly as small molecular weight inhibitors. We herein review synthetic scope and variations, usage, and structural biology of Gewald products.