D. M. Ryan, Julia Ticehurst, M. Dempsey
Nov 1, 1995
Citations
5
Influential Citations
107
Citations
Quality indicators
Journal
Antimicrobial Agents and Chemotherapy
Abstract
GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a novel viral neuraminidase (sialidase) inhibitor which, following intranasal administration in ferrets, is at least 100 to 1,000 times more effective than ribavirin and amantadine against influenza A and B viruses. It retains its activity even when treatments are delayed until 24 h postinfection and has no effect on the serum antibody response to infection.