Linhui Qin, Jianping Wang, Rongrong Zhao
Dec 2, 2019
Citations
0
Influential Citations
24
Citations
Quality indicators
Journal
Journal of agricultural and food chemistry
Abstract
Ginsenoside-Rb1 (Rb1), a major active component of ginseng, has many benefits for cardiovascular disease and diabetes mellitus (DM); but the effect and mechanism on diabetic cardiomyopathy are not clear. In the present studies, we found Rb1-feeding significantly improved cardiac dysfunction and abnormal cardiomyocytes calcium signaling caused by diabetes. This improved calcium signaling was due to that Rb1 reduced Ca2+ leakage caused by over-activated ryanodine receptor 2 (RyR2) and increased Ca2+ uptake by sarcoplasmic reticulum Ca2+-ATPase 2a (SERCA 2a). Furthermore, we found that Rb1 not only enhanced energy metabolism like metformin, eliminated O-GlcNAcylation of calcium handling proteins to regulate calcium signaling, but also directly inhibited RyR2 activity to regulate calcium signaling. This present studies indicated that as a health supplement or drug, Rb1 was a relatively effective auxiliary therapeutic substance for diabetic cardiomyopathy.