L. Best, A. Elliott, J. Davies
1997
Citations
0
Influential Citations
2
Citations
Journal
Advances in experimental medicine and biology
Abstract
D-glyceraldehyde is commonly used as a stimulus of insulin release from the pancreatic β-cell1–3. It is generally accepted that the triose can be metabolized in the β-cell via the glycolytic pathway, thus stimulating insulin release in a manner analogous to glucose1–3. In numerous studies of tumoural β-cell lines which, owing to abnormalities in glucose transport or metabolism, fail to respond to the sugar, glyceraldehyde has been employed as a ‘nutrient’ type stimulus4–6. The results of our studies on glyceraldehyde actions on the HIT-T15 cell line suggest, however, that the triose is poorly metabolized in these cells and that, unlike glucose, it stimulates the β-cell by a mechanism which does not involve its glycolytic metabolism.