J. Crossland, K. Rogers
Aug 1, 1968
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Influential Citations
12
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Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract Rats were rendered catatonic by bulbocapnine and by audiogenic seizures. The glycogen content of the brain fell by approximately 14 per cent in both experimental situations. All parts of the brain lost glycogen, the ‘free’ glycogen fraction being predominantly affected. Brain glucose content rose in both forms of catatonia. In that due to audiogenic seizures, an early rise in the lactic acid content of the brain also occurred but lactic acid was unaffected in the early stages of bulbocapnine catatonia. Adrenal demedullation abolished the hyperglycaemic action of bulbocapnine. It reduced, but did not abolish, the effect of the drug on the glucose content of brain.