F. Bellamy, D. Horton, J. Millet
Apr 2, 1993
Citations
0
Influential Citations
53
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
A series of glycosylated derivatives of benzophenone, benzhydrol, and benzhydril has been synthesized and evaluated for potential activity as venous antithrombotic agents. Studies on structure-activity relationships revealed that compounds having an electron-withdrawing group in the benzhydril or benzhydrol moiety, and specifically those having the beta-D-xylopyranosyl structure in the sugar moiety, were good antithrombotic agents in a rat model of venous thrombosis.