Z. Chen
2007
Citations
0
Influential Citations
1
Citations
Quality indicators
Journal
China Journal of Traditional Chinese Medicine and Pharmacy
Abstract
Objective: To investigate the anti-tumor effect of Glycyrrhiza flavonoids(GF) and its immunological mechanism.Methods: Mice bearing sarcoma 180(S180) were randomized into 3 GF-treated groups and one control group.The mice in GF-treated groups were perfused with GF.Leukocyte and lymphocyte count were taken by the blood cell analyzer.Flow cytometry was performed to detect the percentages of the T cell subsets.Results: Treatment of GF resulted in the tumor inhibition rates of 52.3%(high dose group).Blood total leukocyte and lymphocyte count in GF treated groups were all higher than that in the control group,and there was the most significant increase of the number of immune cells in the high dose GF group(P0.01).Compared with the control group,CD4+/CD8+ ratio and percentage of lymphocytes in the tumor of the 3 GF-treated groups were all obvous higher,the high dose group show the best effect(P0.01).Conclusion: GF exerts its anti-tumor effect possibly through promoting the proliferation and differentiation of immune cells and increasing the immune effector cells in the tumorbearing mice.