Jidong Zhao, W. Xu, Xin Xie
Aug 13, 2018
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0
Influential Citations
29
Citations
Journal
Organic letters
Abstract
A new and convenient strategy for the synthesis of functionalized 1 H-isochromene and 2 H-pyran derivatives based on gold-catalyzed oxidative cyclizations of o-(alkynyl)phenyl propargyl ether derivatives has been developed. The reaction proceeds via gold-catalyzed highly regioselective oxidation, followed by 1,2-migration of an enynyl group and nucleophlic addition. Isocoumarins were also constructed through oxidative cleavage of the exocyclic double bond of the obtained 1 H-isochromenes.