S. Couty, C. Meyer, J. Cossy
Feb 28, 2009
Citations
0
Influential Citations
65
Citations
Journal
Tetrahedron
Abstract
The gold-catalyzed cycloisomerizations of 1,6-ene-ynamides proceed under mild conditions and lead to cyclobutanones from terminal or trimethylsilyl substituted ynamides, or to carbonyl compounds bearing a 2,3-methanopyrrolidine subunit from substrates possessing a propargylic alcohol moiety. High diastereoselectivities are observed with 1,6-ene-ynamides having a stereocenter at the α or β position of the nitrogen atom.