Romain Pertschi, Solène Miaskiewicz, Jean‐Marc Weibel
May 9, 2017
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Influential Citations
14
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Journal
Synthesis
Abstract
Abstract N-Sulfonyl-2-(1-ethoxypropargyl)azetidine derivatives undergo a gold-catalyzed rearrangement in the presence of various alcohols furnishing the 2,5-disubstituted pyrroles in excellent yields (11 examples, 63–86%). Iodide or deuterium trappings of organogold intermediate as well as kinetic study confirmed the postulated cyclization/nucleophilic substitution/elimination mechanism.