Yuqian Xing, Xiao Liu, Qinqin Pu
Sep 10, 2018
Citations
0
Influential Citations
11
Citations
Journal
ACS applied bio materials
Abstract
The G-quadruplex/hemin (G/H) complex has been broadly used in the field of bioanalytical chemistry for peroxidase-mimicking applications. The property of the G/H complex makes it possible to catalyze the decomposition of H2O2. The hydroxyl radical (·OH) generated during the procedure has a higher antibacterial performance than the original H2O2. Herein, an efficient and biocompatible antibacterial system, which provides the same antibacterial efficiency at lower H2O2 concentration to alleviate the H2O2 toxicity, has been demonstrated based on the conversion of H2O2 to ·OH. With the G/H complex as the additive, the antibacterial activity of H2O2 was vastly enhanced against both Gram-positive and Gram-negative bacteria in in vitro experiments. Furthermore, the designed antibacterial system was applied on the mice wound model in vivo and showed outstanding antibacterial activity of the G/H complex to prevent wound infection and facilitate wound healing. Our study renders the possibility of using the G/H complex to help control both Gram-positive and Gram-negative infections.