R. Rapolu, V. P. Raju, Murthy Chavali
Feb 21, 2019
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Journal
Asian Journal of Research in Chemistry
Abstract
Water mediated and environmentally friendly, step-wise an improved synthesis of pimavanserin have been developed from the key intermediate of 1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methyl piperidin-4-yl) thiourea at different solvent conditions. These reactions have an easy workup; provide good to excellent yields, and uses water as the solvent which is considered to be relatively environmentally benign and no need of column chromatography for product isolation.