S. Rao, V. Potluri, R. Potluri
2021
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Abstract
ABSTRACT The main objective of this research is to deliver a large-scale manufacturing procedure by using eco-friendly solvents or green solvents. The core invention of this research is fenoprofen calcium complex preparation with nonchlorinated calcium salt known as Calcium carbonate (CaCO3) in aqueous media without using any organic solvent. This attempt has succeeded without using prior art calcium salt reagents like Calcium chloride (CaCl2) and Calcium hydroxide (Ca(OH)2) and these reagents were used with the combination of organic solvents like ethanol or Acetone by earlier researchers. This article will give an eco-friendly process and improved quality material of Fenoprofen calcium dihydrate as per ICH guidelines.