Dalip Kumar, Gautam Patel, V. B. Reddy
Feb 1, 2009
Citations
0
Influential Citations
28
Citations
Journal
Synlett
Abstract
A convenient and mild protocol for the one-pot regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles in aqueous PEG 400 has been reported. The methodology involves the one-pot reaction ofa-bromo ketones, sodium azide, and terminal acetylenes catalyzed by Cu(I) in aqueous PEG 400 at room temperature. Prominent features of our approach are mild reaction conditions, use of readily available α-bromo compounds, aqueous PEG 400 as a benign reaction medium, avoiding the isolation of labile α-azido ketones, simple workup, and good yields.