Evangelos Aktoudianakis, E. Chan, A. Edward
Apr 1, 2008
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Influential Citations
47
Citations
Journal
Journal of Chemical Education
Abstract
This article describes the rapid, green synthesis of a biaryl compound (4-phenylphenol) via a Pd(0)-catalyzed Suzuki cross-coupling reaction in water. Mild reaction conditions and operational simplicity makes this experiment especially amenable to both mid- and upper-level undergraduates. The methodology exposes students to purely aqueous microscale organic reactivity and showcases topical research in the milieu of an industrially applicable process.