D. Seyferth
Mar 16, 2009
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3
Influential Citations
186
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Journal
Organometallics
Abstract
Most of them are stable in ethereal solution (although atmospheric moisture and oxygen should be excluded) and in general are quite reactive. Discovered by Victor Grignard at the University of Lyon in France in 1900, their ease of preparation and their broad applications in organic and organometallic synthesis made these new organomagnesium reagents an instant success. The importance of this contribution to synthetic chemistry was recognized very early, and for his discovery Grignard was awarded a Nobel Prize in Chemistry in 1912. Our cover molecule is the monomeric ethylmagnesium bromide bis(diethyl etherate) (1), whose solid-state molecular structure was determined by an X-ray diffraction study by Lloyd Guggenberger and Robert Rundle in 1964 using crystals isolated from a diethyl ether solution of a C2H5Br/Mg reaction mixture by slow cooling with a stream of cold gaseous nitrogen.