Anamika Khaskel, P. Gogoi, P. Barman
Aug 13, 2014
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0
Influential Citations
29
Citations
Journal
RSC Advances
Abstract
A single step, mild, environmentally friendly green method has been developed for the synthesis of physiologically active 3,4-dihydropyrimidin-2-(1H)-ones employing L-tyrosine as catalyst under solvent-free conditions at room temperature via grinding. The procedure is efficient, time saving and gives high-yields. The structures and purity of these compounds were confirmed by FT-IR, NMR (1H and 13C) and HRMS spectral analysis. DFT calculations have been used to show the effectiveness of L-tyrosine as a suitable catalyst for the above reaction.