W. Yeo, B. Yun, Young‐Sook Kim
May 25, 2002
Citations
1
Influential Citations
9
Citations
Journal
The Journal of antibiotics
Abstract
Crisamicin A, an isochromanquinone antibiotic, which is produced by Micromonospora sp. has antimicrobial properties1-3). In our previous studies, its derivatives, 9and 1-hydroxycrisamicin A, also showed antimicrobial activity chiefly against Gram-positive bacteria4,5), but not against Gram-negative bacteria and fungi, and was inhibitory to the growth of some human cancer cell lines4). Currently we also found a new antibiotic, referred as GTRIBB (Fig. 1), from the microbial culture that differed from the above antibiotics and crisamicin C6), but was structurally similar to crisamicin A. We report in this paper its structure elucidation and biological properties including cytotoxic and antimicrobial activities. The GTRI-BB-producing strain, Micromonospora sp. SA246, which was already described in the previous study4), was used in this study. Potato-dextrose broth was used for the culture of the microorganism. SA 246 was cultured in 500ml flasks containing each 100ml of the medium for 14 days on a rotary shaker (250rpm) in a