R. Banks, K. N. Mothersdale, A. E. Tipping
Mar 1, 1990
Citations
0
Influential Citations
8
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract Spray-dried potassium fluoride, suspended in sulpholane at 220 °C, converted 2,4- and 2,6-dichlorobenzaldehyde into the corresponding difluoroaldehydes (yields ca . 65%). Small amounts of the mono-substituted products (2-chloro-4-fluoro- + 4-chloro-2-fluoro-benzaldehyde, and 2-chloro-6-fluoro-benzaldehyde, respectively) were also produced. Similar treatment of the 3,4-dichloro-analogue gave 3-chloro-4-fluorobenzaldehyde (yield 98%, conversion 68%), but 2- and 4-chlorobenzaldehyde gave very poor yields ( ca . 5%) of the 2- and the 4- fluoro-derivatives. 2-Fluoro-, 4-fluoro- and 3-chloro-4-fluoro-benzoyl fluoride were obtained (yields 60–65%) by heating the corresponding chlorobenzoyl chlorides with potassium fluoride in sulpholane.