S. R. Kleeb, Márcia dos Santos Rizzo, M. Dagli
Sep 1, 1999
Citations
2
Influential Citations
23
Citations
Quality indicators
Journal
International journal of immunopharmacology
Abstract
Subcutaneous treatment with haloperidol (2.0 mg/kg) was found to increase both the percent of macrophage spreading and nitric oxide (NO) release in peritoneal macrophage from animals inoculated intraperitoneally with 5.0 x 10(6) Ehrlich ascites cells. This haloperidol-induced macrophage activation seems to be involved in its antitumoral effect since cotreatment with the iNOS inhibitor aminoguanidine was able to reverse the inhibitory effect of haloperidol on the development of the Ehrlich solid carcinoma.