W. Burkard, R. Kettler
Jul 15, 1977
Citations
1
Influential Citations
23
Citations
Quality indicators
Journal
Biochemical Pharmacology
Abstract
Abstract Harmaline and its benzo[b]thiophene analogue (“S- harmaline ”) are shown to competitively inhibit monoamine oxidase (MAO). The inhibition was more marked with 5-hydroxytryptamine as a substrate than with tyramine or β-phenylethylamine. After i.p. administration, S-harmaline in contrast to harmaline inhibited the MAO in the brain more potently than in the liver. Harmaline produced a greater and longer lasting increase of cGMP in the cerebellum than S-harmaline. The S-harmaline was also less tremorogenic, thus indicating a connection between cGMP increase and tremor, but not between MAO inhibition and cGMP increase.