T. Norris, C. Bezze, Samuel Franz
Mar 20, 2009
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Influential Citations
14
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Journal
Organic Process Research & Development
Abstract
A green chemistry methodology that uses a heavy-metal-free reduction in aqueous medium is described to produce 5-hydrazinoquinoline [1-(quinolin-5-yl)hydrazine] (6a) as the anhydrous dihydrochloride salt at large scale. The process is entirely aqueous and utilizes l-ascorbic acid to reduce the diazonium salt (2a) derived from 5-aminoquinoline [quinolin-5-amine] (1a).