V. Collot, Didier Varlet, S. Rault
Jun 8, 2000
Citations
0
Influential Citations
42
Citations
Journal
Tetrahedron Letters
Abstract
Abstract In order to design 2-aza bioisosteres of tryptamine, serotonin or melatonin, the conditions of the Heck coupling reaction of 3-iodoindazoles with methyl acrylate are studied. This reaction authorizes the synthesis of 3-indazolylpropenoates as key intermediates to prepare 3-indazolylpropionic acids and 3-indazolylethylamines. The flexible synthetic strategy allows molecular diversity.