A. Zawisza, Benjamin Ganchegui, Iván A. González
Mar 18, 2008
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0
Influential Citations
22
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Journal
Journal of Molecular Catalysis A-chemical
Abstract
Various conditions have been tested to obtain efficiently 2-methyl-1-indanone via the Pd-catalyzed 5-endo-trig cyclization of 1-(o-bromophenyl)-2-methylprop-2-en-1-ol. High yield (97%) was obtained at 120 °C in DMF with Pd(OAc)2/cinchonine as the catalytic system and NaHCO3 as the base. Use of this procedure for the synthesis of other substituted indanones led to lower yields but replacing thermal heating by microwave heating improved greatly the results.