K. Schenker, J. Druey
1963
Citations
0
Influential Citations
8
Citations
Journal
Helvetica Chimica Acta
Abstract
The reaction of 2-(2′-chloroethoxy)-acetophenone (I) with non-hindered primary aliphatic amines is shown to give 4-alkyl-5-methylene-2.3.4.5-tetrahydro-1.4-benzoxazepines (IV) which can be smoothly hydrogenated to the corresponding 5-methyl derivatives VI. Steric limitations of this ring closure are discussed.