P. Schmidt, K. Eichenberger, M. Wilhelm
1959
Citations
0
Influential Citations
26
Citations
Journal
Helvetica Chimica Acta
Abstract
Syntheses of pyrazolo [3,4-d]pyrimidines with an amino group in 3- or 4-position are described. For the preparation of the 3-amino derivatives a 4-chloro-5-cyano-pyrimidine is condensed with various hydrazines. The 4-amino-pyrazolo [3,4-d]pyrimidines are obtained by reacting 3-amino-4-carbethoxy-pyrazoles with formamide, chlorinating thc 4-hydroxy-pyrazolo [3,4-d]pyrimidines, and substituting the halogen by amino groups. Some of the compounds show diuretic and cardiac activity, others inhibit tumor-growth.