Chen Huan-you
2011
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Journal
Journal of Wuhan Institute of Technology
Abstract
Mesosulfuron-methyl was a member of the sulfonylurea group of herbicides.Its mode of action was to inhibit the biosynthesis of essential amino acids in susceptible plants,through inhibition of acetolactate synthase(ALS).The synthesis of the herbicide has been introduced:4-cyano-2-nitro-benzoic methyl ester was synthesized with 4-tolunitrile by nitrification,oxidation and esterification;4-cyano-2-nitro-benzoic methyl ester was hydrogenated and sulfonated to give Methyl 2-sulfonyl-4-methanesulfonylaminomethyl benzoate,which was the key Intermediate of Mesosulfuron-methyl.Then the Intermediate reacted with N-(4,6-dimethoxyprimidin-2-yl)-phenylcarbamate to give the Mesosulfuron-methyl.