S. Al-Mousawi, M. Moustafa, M. Elnagdi
May 29, 2010
Citations
0
Influential Citations
8
Citations
Journal
Arkivoc
Abstract
Reactions of α-S-cyanothioketones 6a-c with malononitrile were observed to form 2-(thiazol- 2(3H)-ylidene)malononitrile derivatives 7a-c. The thiazole products readily react with aromatic diazonium salts to yield 2-(5-phenylazo-3H-thiazol-2-ylidene)-malononitrile derivatives 8a-c. The malononitrile derivative 8c undergoes a condensation with DMF/DMA to yield thiazolo(5,4- c)pyridazine 12. Reactions of 7a-c with hydrazine hydrate leads to the generation of diaminopyrazoles 9a-c, which react with enaminone 13 to yield the corresponding thiazolylpyrazolo(1,5-a)pyrimidines 14. In addition, reaction of the malononitrile derivative 8a with benzenediazonium chloride readily affords the coupling product 10.