Daniel Witthaut, R. Fröhlich, H. Schäfer
Nov 19, 2001
Citations
0
Influential Citations
7
Citations
Journal
Angewandte Chemie
Abstract
The multitalented synthetic reagent trimethyl aconitate (1) is a renewable raw material with a high density of functional groups that up to now has only been scarcely used as a C6 building block. Domino reactions with 1 consisting of imine additions and intramolecular acylations provide simple access to heteropolycycles in one-pot reactions. For example, 1 reacts with N-methylbenzylidenamine (2) to give the spiro[pyrrolidinone-3,3'-dihydropyrrolinone] 3 in 40 % yield.