T. Sugimura, M. Nagao, K. Wakabayashi
Jan 5, 1994
Citations
1
Influential Citations
53
Citations
Journal
Journal of the National Cancer Institute
Abstract
This issue of the Journal has a report by Weisburger et al. (7) who have contributed much to our knowledge about chemical carcinogenesis as well as nutrition and its association with cancer prevention. Weisburger et al. describe the bacterial metabolite 2-amino-3,6-dihydro-3methyl-7//-imidazolo[4,5-/]quinolin-7-one (7-OHIQ), which is formed from a cooked food mutagen and carcinogen, 2-amino-3-methyl-3//-imidazo[4,5-/|quinoline (IQ). Although 7-OHIQ was suspected to induce colon cancer in rodents in vivo, no such result was obtained in this study. In contrast, IQ itself was shown to produce colon cancers by oral administration in rats in our experiments (2). It seems appropriate at this point to comment on the significance of recently found carcinogens existing in cooked food, i.e., heterocyclic amines (HCAs), which are possible candidates for producing commonly occurring human cancers.