Tarawanti Verma, Manish Sinha, N. Bansal
Oct 28, 2019
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Influential Citations
18
Citations
Quality indicators
Journal
Anti-cancer agents in medicinal chemistry
Abstract
Benzene is a six-membered hydrocarbon ring system if three carbon-hydrogen units of benzene ring are replaced by nitrogen atoms then it forms triazine. Triazines are present in three isomeric forms 1,2,3-triazine, 1,2,4-triazine, and 1,3,5-triazine according to position of nitrogen atom. These are weak base having weaker resonance energy than benzene, so nucleophilic substitution is preferred than electrophilic substitution. Triazine is an interesting class of heterocyclic compounds in medicinal chemistry. Numerous synthetic derivatives of triazine have been prepared and evaluated for wide spectrum of biological activities in different models with desired findings such as antibacterial, antifungal, anti-cancer, antiviral, antimalarial, anti-inflammatory, antiulcer, anticonvulsant, antimicrobial, insecticidal and herbicidal agents. Triazine analogs have exposed potent pharmacological activity. So, triazine nucleus may be considered as interesting core moiety for researchers for the development of future drugs.