Hai-yun Xiao, Dauh-Rurng Wu, J. Sheppeck
Oct 15, 2013
Citations
0
Influential Citations
8
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of heterocyclic glucocorticoid receptor (GR) modulators with 2,2-dimethyl-3-phenyl-N-(thiazol or thiadiazol-2-yl)propanamide core are described. Structure-activity relationships suggest a combination of H-bond acceptor and a 4-fluorophenyl moiety as being important structural components contributing to the glucocorticoid receptor binding and functional activity for this series of GR modulators.