Jim Clark, Bahman Parvizi, Robert Colman
1976
Citations
0
Influential Citations
13
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
4-(Substituted amino)-6-chloropyrimidines bearing a mesomeric electron-withdrawing substituent such as NO2, CN, CHO, or Ac at position 5 are cleaved by dilute sodium hydroxide, often at room temperature, to yield tetrasubstituted olefins. Unlike acid-catalysed attacks on similar pyrimidines, the course of these basic reactions was not strongly influenced by steric interference between the 4(6)- and 5-substituents.