S. Smiley, M. Reers, Cristina Mottola-Hartshorn
May 1, 1991
Citations
70
Influential Citations
1,449
Citations
Quality indicators
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abstract
By using a potential-dependent J-aggregate-forming delocalized lipophilic cation, 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine++ + iodide (JC-1), we find that membrane potentials across mitochondria in a living cell can be heterogeneous. Remarkably, even within a long contiguous mitochondrion, regional heterogeneity in membrane potentials appears to be possible.