F. Savelli, A. Boido
Mar 1, 1992
Citations
0
Influential Citations
4
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Pursuing our previous research on azaquinoxalinones (1,2-dihydropyrido[2,3-b]/[3,4-b]pyrazinones) we prepared, through a reductive cyclization of N-(3′-nitropyridin-2′-yl)piperidine-2-carboxylic acids 3a-c, a set of derivatives of a new tricyclic structure, 7,8,9,10-tetrahydro-5H-dipyrido[1,2-a:3′,2′-e]pyrazin-6(6aH)-ones 4a-c. Starting from these compounds we obtained substituted amides 5a-c and, from 4a, the amidines 6a-c. In the synthesis of 6, a dehydrogenation reaction occurred giving rise to 7. The compounds 9 and 10, characterized by a different ring-fusion between the pyridine and pyrazine rings, were synthesized in a similar manner.